The aim of this study was to provide a pooled estimate of the prevalence and odds of depression/anxiety in patients with LP.Ī search and extraction of relevant literature from 5 medical databases (Cochrane Database, EMBASE, PubMed, PsychINFO, Science Direct) was conducted by 2 of the authors (IJ and FR) from inception to 3 October 2019 using the following search terms: (lichen planus) AND (depression OR anxiety OR generalized anxiety disorder OR phobia OR panic disorder OR panic OR obsessive compulsive disorder OR OCD). Previous studies have yielded divergent or conflicting results on the prevalence of depression and anxiety in patients with LP, but the exact magnitude of the association between LP and depression/anxiety is unknown. A recent systematic review found a link between psychological disorders and the development of oral LP (9). The association between certain chronic inflammatory skin diseases and psychiatric disorders or conditions has been well documented (3–8). Although the exact aetiology of LP is unknown, pathogenesis is widely thought to be immune-mediated. LP occurs in approximately 1–2% of the general adult population and commonly affects middle-aged women (2). It most frequently involves the skin and oral mucosa, but other sites can also be affected, such as the genitals, oesophagus, conjunctiva and skin appendages/scalp, hair and nails. Lichen planus (LP) is a chronic inflammatory mucocutaneous condition with a myriad of clinical manifestations (1). These results raise the necessity of screening for the presence of depressive and anxiety symptoms or disorders in patients with lichen planus, and of referring such patients for psychiatric evaluation and appropriate treatment, if necessary. Case-control studies showed a strong association between lichen planus and signs of depression (odds ratio 3.79, 95% confidence interval ) or anxiety (odds ratio 2.54, 95% confidence interval ). The geographical location of the study may partly explain these variations, but methodological differences could also be involved. The meta-analyses showed a high prevalence of signs of depression (27% ) and anxiety (28% ). A systematic review and pooled meta-analyses were performed to examine the prevalence and odds of depression and anxiety in patients with lichen planus. However, the exact magnitude of the association between lichen planus and depression/anxiety symptoms and disorders is unknown. The association between certain chronic inflammatory skin diseases and psychiatric disorders or conditions has been well documented.

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